Nakano, A.
Spinning-disk confocal microscopy: a cutting-edge tool for imaging membrane traffic.  Cell Structure and Function 27: 349-355 (2002).

Confocal laser scanning microscopy is experiencing a revolution in speed from the world of seconds to that of milliseconds. The spinning Nipkow disk method with microlenses has made this remarkable innovation possible. In combination with the ultrahigh-sensitivity, high-speed and high-resolution camera system based on avalanche multiplication of photoconduction, we are now able to observe the extremely dynamic movement of small vesicles in living cells in real time.